ABSTRACT In recent years, researchers have focused on natural antioxidants because they are good for human health. Most scientists believe that around two-thirds of the plants in the world have medicinal value and good antioxidant activity. The goal of this work was to estimate antioxidant activities of plant extracts, collected from Chattogram Hill Tracts, Chattogram. Different types of Plant leaves were extracted with different solvents like water, ethanol, methanol, and Pet ether. These extracts were then tested to see if they have any antioxidant properties using a method called DPPH radical scavenging. The present study found that all plant extracts exhibited remarkable antioxidant activity among them water extract of plants had the highest level of antioxidants followed by ethanol followed by methanol then Petroleum ether extracts. The high antioxidant activity of these might be due to the presence of hydroxyl groups containing substance in polar solvent extract and these hydroxyl groups can damage free radicals and possess the necessary resources for radical scavenging. This study confirms that many plant extracts have very strong antioxidant activity, which can help treat diseases caused by free radicals in the body.
ABSTRACT Due to increasing drug resistance bacterial isolates in hospitals, morbidity and mortality are gradually increasing throughout the globe. Newer antibiotics are also not coming up as most drug manufacturing industries are reluctant to manufacture antibiotics due to low profit. In this context, we have to determine the antimicrobial activities of other common chemical agents. Thus in this experiment, we have studied L-asparagine- an amino acid with various biological activities to find out its antimicrobial activity if any. We were particularly interested in MDR bacteria in this study. Clinically isolated bacteria from different samples were identified by the automated Vitek automated system and stocked in the laboratory for our study. All isolates were used in lawn culture to find out the sensitivity of different bacteria to asparagine. In our experiment, we aimed to find out which specific concentration of L-Asparagine amino acid shows the most potent antibacterial effect on these bacterial species. In general, growths of all tested bacteria found inhibited at a very low concentration of 39 µg/ml. This uniform result against all resistant bacteria tested in this experiment clearly indicates its future utility against all extremely drug resistant bacteria.
ABSTRACT A lipid bilayer including phospholipids, an edge activator, and an ethanol/aqueous core makes up transferosomes, often referred to as transferosomes, which are ultra-deformable vesicles for transdermal applications. Compared to oral and needle-based methods, this approach has a number of benefits, including self-administration, non-invasiveness, significantly reduced hepatic clearance of the medication, and increased patient compliance. The primary reason for the development of various drug delivery systems was that due to the first pass metabolism, adverse and side effects, non-patient compliance and invasive procedures, the efficient therapeutic outcomes. The advantage of transferosomes is they are barely invasive without the first pass metabolism. Transferosomes also has several advantages than liposomes due to the active surfactant properties. Due to its penetration enhancer properties, it enables the drug molecule to penetrate into the skin via the stratum corneum than other formulations. So, more research works are encouraged with respect to tranferosomes in order to formulate various new drugs in this type of drug delivery system.
ABSTRACT When someone develops pancreatitis, their pancreas swells up in inflammation. Pancreatic damage happens when the digestive enzymes are activated before they are discharged into the small intestine and begin attacking the pancreas. There are two types of pancreatitis: acute and chronic. Alcohol consumption and gallstones are just two of the numerous potential causes of pancreatitis. Plant medicine is an effective way to cure pancreatitis. Citrus flavonoids may offer promising bioactive molecules for treating metabolic disorders, according to some research. Hesperidin is widely consumed in the Western diet in this regard, mostly through the consumption of orange juice. Furthermore, since refined hesperidin is easily extracted or produced and is highly purified industrially, it is inexpensively available commercially. The Western diet contains little eriodictoyl, which is mostly found in lemons and is commercially available. Method: In the current work, NF-kβ receptor inhibitors were sought after using a molecular docking approach. The binding was determined by the Auto Dock software utilizing a grid-based docking method. Compounds' 2D structures were constructed using the chem sketch, converted to 3D, and then energetically reduced up to an arms gradient of 0.01. (MMFF). Result: Hesperetin and Eriodictoyl found to be effective anti-pancreatitis agent effectively binds to be target protein NF-kβ receptor with binding energy -6.9 & -6.7 kcalmol-1 for hesperetin & eriodictoyl respectively. Conclusion: It was discovered through a computationally based docking analysis that both lead compounds exhibit strong NF-KB receptor inhibiting effects. The results demonstrated a promising docking score and lead molecule's pattern of binding to the target protein's active region with strong covalent bonding. The synergistic impact of hesperetin & eriodictoyl is ability to heal pancreatitis.
ABSTRACT Dry suspension refers to commercial dry solutions that must be dispensed with water. The bitter taste has had a significant impact on the development of oral preparations and therapeutic uses for numerous toxic medicines. The majority of patients want to take effective treatments that taste good and are easy to administer. It is also defined as an intimate mixture of dry, finely split medication and excipients that, when mixed with an appropriate vehicle, produces a suspension. Reconstitutable suspension is reconstituted at the time of use and can thus be used as a liquid formulation, avoiding swallowing issues. When drug stability is a critical concern, the reconstituted system is the formulation of choice. A variety of commercial and government remedies are available as dry powder combinations or granules that are meant to be suspended in water or another vehicle before being taken orally. The current study attempted to compare assessment criteria by employing three natural gums as a suspending agent in a cefpodoxime proxetil oral dry suspensions: acacia, Trigonella foenum graecum (Family: Leguminosae) seeds, also known as fenugreek seeds, and xanthan gum.
ABSTRACT This research aimed to assess the antioxidant capabilities against DPPH, as well as determine the overall phenolic and flavonoid contents in extracts of abrus precatorius leaves. Different extracts of abrus precatorius leaves were successively prepared using methanol, ethanol, petroleum ether, and distilled water. The DPPH antioxidant capacity of methanol extracts was highest with a low IC50 value of 62.86±0.68µg/mL. Ethanol, water, and petroleum ether extracts also showed significant antioxidant activity with IC50 values of 89.66±0.51, 78.67±0.35, 142±4.26 μg/mL. We observed a significantly higher total phenolic content of 34.67± 2.52 gallic acid equivalent ⁄ g dry extract and total flavonoid content of 27.55±1.84 mg quercetin equivalent/g dry extract for methanolic leaves extract than others. The phenolic content of ethanol and water extract is close enough (22.19±1.45, 26.35±1.65 gallic acid equivalent ⁄ g dry extract). The flavonoid content of ethanol, water, and petroleum ether extract was found as 14.43±1.35, 20.84±1.97, 1.6±0.41 mg quercetin equivalent/g dry extract. These findings will aid in future studies attempting to explore medicinal agents from the abrus precatorius plants of Bangladesh.
ABSTRACT Mothers during lactation may encounter barriers including the need of medication intake due to a chronic or acute illness, which may affect mainly the duration of breastfeeding. In these cases, the issue of medication safety during lactation arises and maternal decisions usually depend on professional counseling. Providing scientifically valid information on the benefits of breastfeeding and the risk of exposure of the newborn/infant to medicines through breast milk is a responsibility of healthcare professionals. Reliable sources on the compatibility of medicines with breastfeeding vary and the information among them is conflicting or even insufficient, creating as a consequence difficulty for healthcare professionals to provide counseling. Given the fact that breastfeeding mothers are excluded from clinical trials as they are considered a vulnerable population, the scientific community has turned to alternative methods based on pharmacokinetic population modeling for medication safety during lactation. In addition, through pharmacovigilance science, databases related to drug compatibility with breastfeeding can be enriched with new data. Undoubtedly, the contribution of midwives and other healthcare professionals involved in breastfeeding plays a key role in the pharmacovigilance process through the observation and reporting of side effects. In the Greek national healthcare system, telephone helplines have been established to provide information on medication safety during lactation. Finally, information is provided on the guiding principles for midwives and other healthcare professionals regarding medication safety in breastfeeding mothers. The ultimate goal is to support and prolong breastfeeding with evidence-based knowledge.
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Mst. Tanzina Islam
Nursing Instructor, Naogaon Nursing Institute, Naogaon, Rajshahi, Bangladesh
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