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Introduction: Gerontology defined by the Royal Spanish Academy as the science that deals with old age and the phenomena that characterize it. Likewise, knowledge of the sciences of aging has relevant importance in clinical application, specifically at the first level of health care Objective: Identify and reflect on the applications of gerontology as a science in the clinical setting Methodology: A systematic review of scientific literature on gerontology carried out, using scientific search engines: Latindex, Scielo, PubMed and Semantic Scholar. In this sense, two categories focused on for the systematic analysis of the information: 1) Gerontological conceptual approaches, and 2) Professional competencies in the clinical field. Results: Nine articles published between 2016 and 2023 reviewed. In this sense, the identified findings are conceptual approaches and intervention methods in the clinical setting Conclusions: Gerontology is a science with little scientific literature and sufficient research regarding clinical intervention in professional settings. Consequently, recommended to design and execute actions from Higher Education Institutions and public policy to highlight the importance of gerontology in society.

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Abstract: Haematopoietic stem cell transplantation, chemotherapy, and radiation therapy are frequently linked to the crippling condition known as oral mucositis (OM). It can seriously impair quality of life and possibly interfere with cancer treatment plans. It manifests as painful ulceration, erythema, and oedema. Microbiota dysbiosis, oxidative stress, and inflammatory pathways are all intricate components of the pathophysiology of OM. Its severity is influenced by several risk factors, such as chemotherapy, radiation dosage, genetic predisposition, and oral hygiene. There is still no ideal gold-standard treatment for it, despite its high prevalence. Pharmacological interventions like cytoprotective agents, anti- inflammatory medications, growth factors, biological response modifiers, and antimicrobial agents are all part of the multimodal approach used in current management strategies. Low-level laser therapy (LLLT), cryotherapy, and dental hygiene practices are examples of non-pharmacological methods that have demonstrated promise in reducing symptoms and enhancing patient outcomes. Recent developments in OM pathophysiology and treatment approaches are compiled in this review, which highlights the importance of tailored, evidence-based treatment plans. To improve patient care and reduce OM-related morbidity, more research is necessary to create innovative, affordable, and widely recognized treatments.

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Persistent cytopenias, defined by a prolonged decrease in blood cells, are common clinical signs in various malignant hematological disorders, such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Diagnosis relies on a thorough evaluation, including biological tests, notably bone marrow analysis, and sometimes genetic and molecular tests. Treatment of these conditions includes azacitidine and venetoclax, whose combined effectiveness has shown promising results, although side effects such as neutropenia require careful management. This article presents a case of AML treated with this combination, with continuous evaluation of disease progression, genetic mutations, and treatment resistance.

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Multiple myeloma, a malignant hematologic disorder characterized by excessive monoclonal plasma cell proliferation in the bone marrow, is rare in individuals under 40, comprising less than 2% of cases. This report details a 27-year-old patient with left-sided lumbosciatica and clinical signs of lumbar and radicular syndrome at the S1 level. Imaging revealed multiple osteolytic lesions with perilesional sclerosis and abnormalities in the first sacral foramen. Biological findings included normochromic normocytic anemia, hypercalcemia, elevated sedimentation rate, monoclonal IgG Kappa, free Kappa light chains, hyperproteinemia, and hypoalbuminemia. A bone marrow biopsy confirmed 95% plasma cell infiltration. The patient underwent a VRD regimen and three cycles of D-VRD and is awaiting autologous stem cell transplantation. This case underscores the need to consider multiple myeloma in young patients, as failure to do so could delay critical diagnosis and treatment.

ABSTRACT
Artificial intelligence (AI) stands at the forefront of modern scientific innovation. It has revolutionized our understanding of the world around us and its effects on Zoology also called as animal science have been profound. With continued advancements in AI technology, new opportunities to explore the unknown will continue to arise offering us unprecedented insight into this fascinating field. AI technology offers immense potential for animal scientists to improve their work. Automated tracking and predictive analytics allow data analysis on an unprecedented scale, enabling greater insight into complex biological systems than ever before. This can lead to improved animal welfare through better resource optimization, as well as more informed decision making in conservation efforts. AI also helps to reduce the workload of researchers by automating mundane tasks that would otherwise take a long time to complete. The good news is that it’s unlikely that AI will completely replace animal scientists any time soon; however, certain roles within the field may become automated by technology over time. So while it’s important to pay attention to advances in AI technology, it’s also possible to use them for advantage and secure the place in the workforce of tomorrow. Moreover, this technology continues to evolve, so too will its impact on our lives and careers.

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Ethiopia is the center of origin and has a varied genetic foundation for Arabica coffee, but there is still a lack of yield-competitive enhanced varieties, which is why the average productivity in the country is significantly lower than the global average. The average national productivity is quite low as a result. To find high-yielding coffee for commercial usage, it may be helpful to further assess the performance of the top-performing selections for growth and yield characteristics at the full bearing stage. Therefore, it is crucial to create pure line coffee types that are stable, disease resistant, and high yielding in order to close this gap and increase coffee productivity. Thus, the purpose of this study was to assess the genotypes of pure lines coffee for yield and yield components. In order to illustrate the growth and yield characteristics of eleven Arabica pure line coffee genotypes and three standard checks, the experiment was carried out at Awada, Leku, and Wonago. A randomized complete block design (RCBD) with three replications was used to carry out the experiment between 2015 and 2020. Data were gathered on plant height, number of primary branches, number of secondary branches, length of the longest primary branch, number of main stem nodes, stem girth, internode length on the main stem, canopy diameter, number of nodes on longest primary, and yield per hectare. The findings showed that there were differences between the growth features. Total plant height (1.88–3.34 m), stem diameter (2.93–4.42 cm), canopy diameter (153.58–195.17 cm), number of main stem nodes (30.47–42.00), primary branch number (59.93–82.93), secondary branch number (12.97–37.80), average length of primary branches (92.50–116.10 cm), and number of nodes on longest primary (18.43–29.07) at Awada. Stem diameter (2.78–4.20 cm), canopy diameter (171.19–216.33 cm), number of main stem nodes (29.27–34.93), inter node length on the main stem (4.99–6.77 cm), number of primary ...

ABSTRACT
Thiaminase (EC 2.5.1.2) is an enzyme that cleaves thiamine into its pyrimidine and thiazole moieties resulting in thiamine deficiency in various organisms. It is classified into two main types: Thiaminase I and Thiaminase II defined by the nucleophile used in the mechanism by which the cleavage is accomplished. Thiaminase I employs a variety of nucleophiles including, amines and sulfhydryl compounds while thiaminase II exclusively uses water for hydrolysis of thiamine. The crystal structure of thiaminase I reveals a deep cleft that accommodates thiamine and highlighting important residues that assists in its breakdown. This process disrupts thiamine’s biological function leading to metabolic disturbances. Physiochemically, thiaminase exhibits specific properties that influence its activity, such as optimal pH of 4-8 and temperature ranges from 40-60◦c. Thiaminase is naturally found in various organisms including certain plants, bacteria and marine animals where it can act as an antinutrient. Consequently, thiaminase activity elicits life threatening conditions such as beriberi and Wernicke-korsakoff syndrome due to thiamine depletion. Furthermore, this can lead to significant neurological conditions, including ataxia and peripheral neuropathy. Interestingly, studies have suggested that native thiaminase and Polyethylene glycol-modified (PEGylated) thiaminase I enzyme may have potential applications in cancer therapy by impairing mitochrondrial respiration in cancer cells. This suggests that thiaminase may likely be a potential source of novel cancer chemotherapeutic agent via the impairment of DNA synthesis and energy metabolism in cancerous cells.