EAS Publisher | East African Scholars Journal of Medical Sciences

36 Downloads | April 14, 2025

Original Research Article

Prevalence and Risk Factors of Vitamin D Deficiency in Rural Population
Mahbubur Rahman, Dilruba Ibrahim Dipti, Meherdad Yousuf Ahmed
East African Scholars J Med Sci, 2025: 8(4): 122-128
https://doi.org/10.36349/easms.2025.v08i04.002

Abstract

29 Downloads | April 12, 2025

Original Research Article

Comparing the Effect of Exercise and Metformin on Pancreatic Beta Cell Function in Nigerians with Prediabetes: A Randomized Controlled Trial
Umar M Tambuwal, Sabir A Ahmad, Sada K Bello, Umar Hayatu, Maiyaki A Sadiq, Jimoh A Kolawole, Abdullahi U Faruk
East African Scholars J Med Sci, 2025: 8(4): 114-121
https://doi.org/10.36349/easms.2025.v08i04.001

Abstract

59 Downloads | April 5, 2025

Original Research Article

Rutin and Vitamin C Improved Neurobehavioral Parameters and Cerebellar Cytoarchitecture in Monosodium Glutamate and Alcohol Induced Neurotoxicity in Male Wistar Rats
Rejoice Buduchim Buduburisi, Godspower Onyeso, Onyebuchi Obia, Justice Buduka Otto
East African Scholars J Med Sci, 2025; 8(3): 107-113
DOI: https://doi.org/10.36349/easms.2025.v08i03.004

Abstract

83 Downloads | March 21, 2025

ABSTRACT
Toxins can alter the nervous system in ways that can disrupt or damage the brain or peripheral nervous system because of repeated exposure to natural or man-made toxic substances. The present study aims to investigate the neuro-behavioral and cytoarchitecture protective functions of rutin and vitamin C in monosodium glutamate and alcohol induced neurotoxicity in male Wistar rats. After two weeks of acclimatization, the animals were randomly selected into ten (10) groups with each group having five animals each (n=5). Neurotoxicity was induced with an oral single daily administration of 30% alcohol and 1.5g/kg body weight of Monosodium glutamate for 28 days consecutively in all rat groups except group1. The animals were subsequently treated as follows: Group 1: Control; animals in this group had free access to water and laboratory rat chow. Group 2: MSG only; animals in this group received no additional treatment after induction of neurotoxicity with a single daily administration of 1.5g/kg of MSG. Group 3: Alcohol only; animals in this group received no additional treatment after induction of neurotoxicity with a single daily administration of 30% alcohol. Group 4: MSG + Alcohol; animals in this group got no treatment after the induction of neurotoxicity with a single daily administration of 1.5g/kg of MSG and 30% alcohol. Group 5: MSG + Alcohol + Rutin; animals in this group received 30mg/kg of rutin following induction of neurotoxicity. Group 6: MSG + Alcohol + Vitamin C; animals in this group received 200mg/kg of vitamin C following induction of neurotoxicity. Group 7: MSG + Rutin; animals in this group received 30mg/kg of rutin following induction of neurotoxicity. Group 8: MSG + Vitamin C; animals in this group received 200mg/kg of rutin following induction of neurotoxicity. Group 9: Alcohol + Rutin; animals in this group received 30mg/kg of rutin following induction of neurotoxicity. Group 10: Alcohol + Vitamin C; animals in this group received 200mg/kg ...

Review Article

Diverse Pathways of Climate Changes and Environmental Factors on Tuberculosis and Infectious Diseases
Jacob Oluwoye, Lola Akinbode
East African Scholars J Med Sci, 2025; 8(3): 101-106
DOI: https://doi.org/10.36349/easms.2025.v08i03.003

Abstract

102 Downloads | March 15, 2025

Original Research Article

Factors Associated with Pulmonary Hypertension in Acynotic Congenital Heart Disease with Left to Right Shunt
Dr. Shayla Afroze, Dr. Mahmudul Huq Chowdhury, Dr. Meherdad Yousuf Ahmed
East African Scholars J Med Sci, 2025; 8(3): 96-100
DOI: https://doi.org/10.36349/easms.2025.v08i03.002

Abstract

839 Downloads | March 6, 2025

ABSTRACT
Background: The most frequent type of cardiac abnormality in childhood is left-to-right shunting in acyanotic congenital heart disease (CHD). Delays in CHD care are caused by limited access to professional health services. Limited facilities, delayed diagnosis, and family economic factors all make it difficult to close the shunt in a timely manner, increasing the patient's risk of developing pulmonary hypertension. Objective: To determine the factors that influence pulmonary hypertension in pediatric patients with left to right shunting in acyanotic congenital heart diseases. Materials and Methods: This observational study was included children with acyanotic CHD left-to-right shunting who were admitted in the Department of Pediatric Cardiology in Bangladesh Shishu Hospital & Institute (BSHI), Dhaka, from 1st January to 31st December 2024. Total 140 patients aged between 1 month to 17 years with isolated atrial septal defect, or ventricular septal defect, or patent ductus arteriosus were included. Patients who had abnormalities that limited blood flow to the lungs, such as pulmonary stenosis, disorders that limited systemic blood flow such as aortic stenosis, aortic coarctation, mitral stenosis, as well as patients with rheumatic heart disease, cardiomyopathy, and infective endocarditis were excluded. Results: Younger children are more likely to develop pulmonary hypertension (p < 0.05). About four-fifth 55 (78.57%) of the participants had single congenital anomaly. Out of the remaining 6 (8.57%) children ASD e PDA was 4 (5.71%), ASD and VSD was 3 (4.29%), VSD e PDA was 3 (4.29%) respectively. Heart failure was substantially higher in the pulmonary hypertension group compared to the no pulmonary hypertension group (42.86% vs. 10%, p<0.001). The findings revealed that heart failure was a strong predictor of pulmonary hypertension, with a hazard ratio of 4.1. Conclusion: Patients with acyanotic CHD and heart failure who underwent left-to-right shunting have a four-...

Original Research Article

Effect of Oral Administration of Common Pepper Types on the Liver Enzymes of Wistar Rats Fed with High-fat Diet
Onyebuchi Obia, Furo Dawari Emmanuel
East African Scholars J Med Sci, 2025; 8(3): 92-95
DOI: https://doi.org/10.36349/easms.2025.v08i03.001

Abstract